Endocrine Abstracts

About 10–15% of prolactinomas (P) are resistant to Dopamine agonists (DA). We analyzed retrospectively ten resistant prolactinomas (RP) treated at our center between 1995 and 2014, to identify useful variables to predict DA resistance and its different patterns (biochemical resistance (BR), morphological resistance (MR) or both). BR is defined as the failure to normalize prolactin (PRL) levels with ≥ 2 mg/week of cabergoline (C) for at least 3 months. MR is consider...

We report the case of a Caucasian woman presenting with a challenging differential diagnosis of ophtalmopathy. The patient was diagnosed with Graves’ disease during postpartum at the age of 28 (TSH<0.001 U/ml; FT3 6.7 ng/dl; FT4 2.2 ng/dl; TSAb 15 U/l). Besides 16 pack-year smoking history, no other previous disease was known. At examination, exophthalmos grade I/III with bilateral lid retraction was evident. Persistency of the disease despite optimal use of medical a...

Objective: The aim of this study was to evaluate the treatment outcomes in patients with autonomous toxic nodule (ATN) that received a radioiodine treatment (RAIT) and to determine the influence of age, gender, nodule size and iodine activity.Methods: We performed a retrospective study of all RAIT done for hyperthyroidism (n=149) in our hospital during 2014 and 2015. Patients with ATN submitted to RAIT were selected to analysis. We studied 58 pa...

Background: Thyroid hormones modulate the lipoprotein and glucose metabolisms. In hyperthyroidism, insulin resistance is a frequent finding.Aim: To assess interrelationships between thyroid function, autoimmunity, lipid profile, glucose metabolism and other cardiovascular risk factors in patients with Graves’ disease.Methods: We recorded free T3 (FT3), free T4 (FT4), TSH, TSH receptor antibodies (TRAB), parameters of the lipid...

Introduction: Activation of the hypothalamic–pituitary–adrenal axis is critical for adaptation to stress and serious illness. The imbalance between anti-inflammatory activity of cortisol and proinflammatory activity of the androgens, dehydroepiandrosterone (DHEA) and dihydroepiandrosterone sulfate (DHEAS) can be an important predictor factor of mortality in sepsis.Material and methods: Patients diagnosed of severe sepsis or septic shock admitte...

Introduction: In patients with autoimmune thyroiditis, thyroid function appears to be related to increased cardiovascular risk. It was our objective to evaluate the relationship between TSH, insulin resistance, lipid profile, C-reactive protein (CRP) and homocysteine in patients with autoimmune thyroiditis (AIT).Methods: We analyzed the lipid profile, the CRP, anti-thyroid antibodies, homocysteine, folic acid, vitamin B12 levels and the insulin resistanc...

Introduction: Pituitary macroincidentalomas are rare, being found in only 0.2%–0.3% of the patients that undergo imaging studies for an unrelated reason. The majority of them are non-functioning adenomas.Case Report: Woman, 77 years-old, with type 2 diabetes mellitus, hypertension and primary hypothyroidism. She was referred to Endocrinology due to a pituitary incidentaloma (18 mm of maximal diameter, with extension to the cavernous sinus and to the...

Introduction: Adequate glycaemic, along with other cardiovascular risk factor control in type 2 Diabetes (T2D), and its beneficial impact on subclinical inflammation is associated with better microvascular outcomes.Objectives: To analyse the correlation between glycaemic control adequacy and systemic inflammatory markers, renal disease progression and cardiovascular risk factors.Material and methods: Retrospective cohort observatio...

Background: Subclinical hyperthyroidism (SHT) is associated with harmful effects on cardiovascular system, bone metabolism and progression to clinical hyperthyroidism. Loss of weight is a common fact in patients with clinical hyperthyroidism and of particular relevance in elderly patients, who are vulnerable to sarcopenia.Objective: To assess changes in body composition after radioiodine therapy for SHT due to toxic nodular goitre....

The thyroid pathology is an area of special interest in our department. Hyperthyroidism represents 3.4% of the 8144 patients followed.The aim of this study is to characterize the therapeutic approach in patients with Grave’s disease (GD) and toxic nodular disease (TND).Retrospective study of 217 patients diagnosed with GD and TND, evaluated according parameters of therapeutic option, efficacy, relapse rate and associated compl...